06-05-2024
My research interests center on enzyme mechanisms. The most significant investigations in my laboratory have focused on the characterization of pathways for metalloenzyme synthesis and the elucidation of catalytic mechanisms for metal-containing enzymes, with particular emphasis on the nickel-containing enzymes lactate racemase and urease along with iron- and 2-oxoglutarate-dependent oxygenases that include representatives involved in DNA repair, sulfonate metabolism, and ethylene biosynthesis. Most of these projects involve bacterial metabolism and physiology, but we have also worked on systems from fungal, protozoal, and mammalian cells.
